Biostimulators

At San Diego Eyelid Specialists we offer a variety of Biostimulators to help reverse the aging process, battle stubborn wrinkles, and improve acne scars (and regular scars) by boosting collagen synthesis. We offer these biostimulators:
• Sculptra
• Radiesse
• PRP
• PRF

Sculptra

2

Sculptra is a synthetic biostimulator made of PLLA (Poly-L-Lactic Acid) when injected, can stimulate collagen and volumize hollowed areas on the face and other body parts. 3 sessions are required, 6 weeks apart. Swelling for 2-7 days is common, and then it looks like nothing happened for a while. After 6 weeks you will be able to appreciate a slight difference, right in time for the second session. 6 weeks after the third session is when you’ll really see those results.

Radiesse

1

Radiesse is considered a biostimulator despite being equally great at filling! It’s made of a substance called Calcium Hydroxyapatite, which mimics bone composition under the skin. Not to be confused with feeling like bone, results are smooth and long-lasting (~1-2 years). The best application is for hand filler (on the back of your hand) to add volume and decrease the appearance of veins and tendons. Radiesse swells for about 3 days, we call it “Mickey Mouse hands”

PRP

Platelet Rich Plasma, also known as “PRP” is an injection treatment whereby a person’s own blood is used. A fraction of blood (20cc) is drawn up from the individual patient into a syringe. This is a relatively small amount compared to blood donation which can remove 500cc. The blood is spun in a special centrifuge to separate its components (Red Blood Cells, Platelet Rich Plasma, Platelet Poor Plasma, and Buffy Coat). The Platelet Rich Plasma and Buffy Coat are first separated and combined then activated with a small amount of calcium chloride which acts as an activation agent and scaffold to keep the PRP where the injector intends to treat. Platelets are very small cells in your blood that are involved in the clotting and healing process. When PRP is injected into the damaged area it causes a mild inflammation that triggers the healing cascade. As the platelets organize in the treatment area, they release a number of enzymes to promote healing and tissue responses including attracting stem cells and growth factors to repair the damaged area. As a result, new collagen begins to develop. As the collagen matures, it begins to shrink causing the tightening and strengthening of the damaged area. When treating injured or sun and time damaged tissue, they can induce a remodeling of the tissue to a healthier and younger state. The full procedure takes approximately 45 minutes to an hour. Generally, 2-3 treatments are advised, however, more may be necessary for some individuals. Touch up treatments may be done once a year after the initial group of treatments to boost and maintain the results.

PRP’S SAFETY has been established for over 20 years for its wound healing properties and it’s proven effectiveness has extended across multiple medical specialties including cardiovascular surgery, orthopedics, sports medicine, podiatry, ENT, neurosurgery, dental and maxillofacial surgery (dental implants and sinus elevations), urology, dermatology (chronic wound healing), and ophthalmology, cosmetic surgery. PRP’s emergence into aesthetics and skin rejuvenation began in 2004 in Europe, Asia, Australia, and South America in countries such as The United Kingdom, Japan, Spain, Portugal, Switzerland, and Argentina to name a few. Areas typically treated for aesthetic purposes and skin rejuvenation include: Crinkling skin around the eyes, cheeks and mid­face, neck, jaw-line, chest and décolletage, back of hands and arms, lips, and to stimulate hair growth on scalp. Almost all skin tones show that PRP is safe and effective because your own enriched plasma is used.

BENEFITS OF PRP: Along with the benefit of using your own tissue therefore virtually eliminating allergies, PRP has been shown to have overall rejuvenating effects on the skin including improving skin texture, thickness, fine lines and wrinkles, increasing volume via the increased production of collagen and Elastin, and by diminishing and improving the appearance of scars. The most dramatic results to date have been the crepey skin problems in areas such as under the eyes, neck, and décolletage. It is not designed to replace cosmetic surgery as there are some cases where those procedures would be more appropriate. Other benefits include: minimal downtime, safe with minimal risk, short recovery time, natural-looking results; no general anesthesia is required.

CONTRAINDICATIONS: PRP used for aesthetic procedures is safe for most individuals between the ages of 18-80. Parental Consent required .for patients under 18. There are very few contraindications, however, patients with the following conditions are not candidates: 1) Acute and Chronic Infections
2) Skin diseases (i.e. SLE, porphyria, allergies) 3) Cancer 4) Chemotherapy treatments 5 ) Severe metabolic and systemic disorders 6 ) Abnormal platelet function (blood disorders, i.e. Haemodynamic Instability, Hypofibrinogenemia, Critical Thrombocytopenia) 7) Chronic Liver Pathology 8) Anti-coagulation therapy, 9) Underlying Sepsis and 10) Systemic use of corticosteroids within two weeks of the procedure.

RISKS & COMPLICATIONS: Some of the Potential Side Effects of Platelet Rich Plasma include: 1) Pain at the injection site; 2) Bleeding, Bruising and/or Infection as with any type of injection; 3) Short lasting pinkness/redness (flushing) of the skin; 4) Allergic reaction to the solution; 5) Injury to a nerve and/or muscle as with any type of injection; 6) Itching at the injection site(s); 7) Nausea/vomiting; (The following are possible with any simple injection and not specific to PRP Therapy).8) Dizziness or fainting; 9) Temporary blood sugar increase; 10) Swelling; 11) Minimaleffect from the treatment.

ALTERNATIVES to PRP: Alternatives to PRP are: 1) Do Nothing; 2) Surgical intervention may be a possibility; 3) Injections with neurotoxins; 4) Injections of dermal filling agents; 5) Laser & light-based treatments like Pulsed Light; 6) chemical peels.

RESULTS: Results are generally visible at 4 weeks and continue to improve gradually over ensuing months (3-6) with improvement in texture and tone. Advanced wrinkling cannot be reversed and only a minimal improvement is predictable in persons with drug, alcohol, and tobacco usage. Severe scarring may not respond. Current data shows results may last 18-24 months. Of course, all individuals are different so there will be variations from one person to the next.

PRF

PRF means Platelet Rich Fibrin. This is not to be confused with PRP, which is Platelet Rich Plasma.

Platelet-Rich Fibrin (PRF) uses the most advanced Blood Concentrate technology to generate a Fibrin Matrix rich in Platelets, Leukocytes, and Mesenchymal Stem Cells.

This process results in the constant release of growth factors and interleukins for 10-12 days after an introduction that accelerates tissue healing and skin regenerating processes. This 100% autologous rejuvenation technique is a substantial advancement from the well-established PRP (Platelet-Rich Plasma) technique where growth factors are all released only for a few minutes after treatment.

This is all-natural. There is no coating, additive, or anticoagulant present in the tubes and it is proven to release a higher concentration of growth factors for a longer period of time. Bottom line, PRF contains Stem Cells and PRP does not.

INDICATIONS

Skin and hair rejuvenation: Skin tightening, improved skin texture, and quality, as well as collagen stimulation and hair restoration.

TREATMENTS

In Cosmetic surgery, PRF is used to accelerate the wound healing process and reduces scarring. In Aesthetics, PRF is used to treat alone or in combination with collagen induction therapy to treat:

4

– Hair loss
– Dark circles
– Acne scarring
– Wrinkles and fine lines
– Tear throughs and deep folds
– Brown spots (face, neck, décolleté)
– Volume loss and symmetry adjustment

3

This treatment is highly dependable on the level of hydration of the patient (patients need to start hydration process 72 hours before treatment). Patients who smoke may have less response to this treatment.